• CBEC Lab

Mass Spec and Proteomics > Our Staff


Arpad Somogyi
Arpad Somogyi, PhD - Associate MS&P Facility Director - somogyi.16@osu.edu - Publications (PDF)
As the Associate Director of the CCIC MS&P Facility, I oversee the day-to-day operation, generate proposals for additional new instruments and upgrades, and interact with faculty, posdocs and students to ensure that their analytical needs are met in the most efficient way possible. I enjoy consulting with colleagues from different research areas. I have many years of experience in mass spectrometry. Specifically, my main interest include studying peptide fragmentation mechanisms, gas-phase H/D exchange, synthetic polymer analysis, astrobiological applications, biological, biochemical and proteomic applications. I have been working with wonderful colleagues on many exciting research areas, the results of which are summarized in 104 peer reviewed publications.

Liwen Zhang
Liwen Zhang, PhD - Technical Director for Proteomics - zhang.287@osu.edu - Publications (PDF)
I am the Technical Director for OSUCCC Proteomics Shared Resources (PSR) at the CCIC/MS&P Facility. I work extensively in the identification of proteins, protein-protein binding partners, post-translational modifications, crosslink oramino acid mutation of proteins, as well as label-free or isotope-labeling protein quantitation using mass spectrometry coupled with chromatography. I have almost 20 years of experience with many aspects of mass spectrometry and have been working in the facility for 17 years. I am responsible for the daily operation of the OSUCCC Proteomics Shared Resources. Working together with other colleagues, we provide consultant for experiment design, sample preparation, LC-MS/MS analysis, data analysis/interpretation and assist for publications or grant submission. I also participate in teaching and promoting mass spectrometric education by training graduate students on Orbitrap operation and demonstrating MS experiments to graduate and college students. My collaboration with the facility users has led to almost 50 peer-reviewed publications, one book chapter, and two pending US patents. I completed my graduate research at The Ohio State University under the supervision of Dr. Michael A. Freitas (currently at The Ohio State University).

Nan Kleinholz
Nan Kleinholz, BS - Senior Research Associate - kleinholz.1@osu.edu
I am the Instrument Coordinator of the the CCIC MS&P Facility. I have worked in MS&P since 2000 and have combined laboratory experience of 27 years. I am in charge of ensuring the safe and optimal operation of the ESI and MALDI mass spectrometers and HPLC’s. I perform routine maintenance and repair as necessary. I conduct complex and independent experimentation within the MS&P. I counsel and advise our customers on experiments and data analysis. I also train staff and self-operation users.

Sophie Harvey
Sophie Harvey, PhD - Research Associate 2 - harvey.486@osu.edu
I work on proteomics samples within the OSU Mass Spectrometry and Proteomics Facility. This includes identifying proteins using bottom-up approaches and top-down approaches as well as intact protein or protein complex measurements. I work on identifying post translational modifications, as well as label-free or isotope labelled samples for quantitation. My work mostly uses the Thermo Orbitrap Fusion, Thermo Q Exactive Plus, Thermo Orbitrap XL instruments, and the 15T FT ICR MS. My role also includes data analysis of these samples using a variety of different software packages-including Mascot and Proteome Discoverer. Prior to working in the facility I received my PhD from the University of Edinburgh working under the supervision of Perdita Barran, using MS and ion mobility-MS to study conformationally dynamic proteins and their interactions with small drug molecules or biomolecules. Following this I did postdoctoral research in the lab of Vicki Wysocki at The Ohio State University studying the structure of protein complexes, and membrane protein complexes, using MS and IM-MS.

Matt Bernier
Matthew Bernier, PhD – Research Associate 2 - bernier.19@osu.edu
I am the small molecule, accurate mass, and metabolomics facilitator here at the Mass Spectrometry and Proteomics Facility. My work here at the facility began in early 2017 after first finishing my PhD with Vicki Wysocki at OSU in 2014 and doing Post-Doctoral work at Georgia Tech with Dr. Facundo Fernandez. My main research areas of focus have mainly involved small molecule peptide fragmentation fundamentals, ambient ionization development, and high-resolution analysis. I have experience working with small molecule analysis of complex mixtures from many sources and have used many instrument platforms from GCMS to ICR along with small molecule analysis with ion mobility on Waters Synapt G2 instrumentation. In the facility, I use mainly the ThermoScientific Quantiva triple quadrupole for targeted metabolomics and the Thermo Q-Exactive plus for untargeted metabolomics for the majority of projects. I also train users in the operation of the triple quadrupole, the GCMS Thermo DSQ instrument, and run accurate mass analysis on our 15 T Bruker ICR. In addition, for both targeted and untargeted small molecule metabolomics I use our data analysis programs, particularly Progenesis and other open source software, to identify targets of interest and perform the appropriate statistical analysis for the highest quality data for submitted projects.

Sean Cleary
Sean Patrick Cleary – Research Associate 2 - cleary.186@osu.edu
Here at the facility, I work on the research and development of analytical pipelines using both commercial and open-source based software for the analysis of both targeted and untargeted metabolomics, as well as the statistical analysis and data mining of highly complex data sets. I am a physical chemist by training, where prior to joining the CCIC, I received my PhD in chemistry from the University of Oregon under the guidance of Jim Prell, where I worked on the development of open-sourced analytical tools for the deconvolution of highly complex data sets and complexes acquired using native mass spectrometry.

Andrew Reed
Andrew Reed, PhD – Research Associate 2 - reed.1287@osu.edu
I am biochemist by training, who focuses on the protein biochemistry aspect of proteomics research. This largely includes advising or performing preparation of protein samples for mass spectrometry experiments. I have extensive experience with cloning and protein construct design, protein expression in bacterial and eukaryotic (insect cells) systems, and protein purification. Prior to working at the CCIC, I received my PhD from The Ohio State University while studying under the guidance of Dr. Zucai Suo, where I performed structural and biochemical characterization of enzymes related to DNA replication and repair. Through this work I have gained extensive experience in protein production, as well as enzyme kinetics. In addition, I have a great understanding of protein complex interactions (protein-protein and/or protein-DNA/RNA) and their associated dynamics.

Kris Fox
Kris Fox – CCIC and CMIF Business Administrator - fox.1105@osu.edu
Kris is an experienced fiscal and human resources administrator with a Bachelor of Science in Finance. Within CCIC and CMIF, she is responsible for all fiscal, procurement, customer billing, policy development, grant administration, reconciliation, travel coordination and human resource activities. She is also responsible for fiscal analysis, reporting and developing, tracking and analyzing the budget.

Ciara Donovan
Ciara Donovan - CCIC and CMIF Business Assistant - donovan.272@osu.edu
I am the Business Assistant for the CCIC and CMIF here at The Ohio State University. I support the CCIC and CMIF Business Administrator with fiscal services such as purchasing, invoicing, customer billing, reconciliation and the tracking/analyzation of funding and budgets. I am also responsible for reporting, travel coordination and event coordination assistance.